Дигоксин 0.25 мг 40 таблеток

Form

tableti

Dosage mg

0.25

Pack

40

DIGOXIN Active Ingredient: Digoxin Clinical-Pharmacological Group: Cardiac Glycoside. Composition and Dosage Form: Tablets: 40 tablets per pack. 1 tablet Digoxin ....................... 0.25 mg Pharmacological Properties: Digoxin is a cardiac glycoside of the digitalis group. With its direct effect on the myocardium, it increases its contractile force, causes an increase in cardiac systolic and minute volume, strengthens systole, prolongs the refractory period, and slows down heart rate. Digoxin is well absorbed from the gastrointestinal tract. It is eliminated by the kidneys. Its action is observed 1-2 hours after administration and reaches its maximum 6-8 hours after administration. See blog: Digoxin for Proper Heart Function: When and How to Use the Preparation Indications: Tachyarrhythmic form of atrial fibrillation with heart failure; in combination with other agents for advanced heart failure. Administration Rules and Dosage: The dosage of the preparation is individual. When dosing, the patient's body weight, creatinine clearance, and disease severity should be considered. In adults: The initial dose is 0.5 mg to 0.75 mg, followed by 0.125 mg to 0.375 mg every 6-8 hours until clinical improvement symptoms are achieved. For patients weighing 70 kg, the total loading dose is 0.75 mg to 1.25 mg. In children: 2 to 5 years old: total dose is 30-40 mcg/kg, maintenance - 25-35% of the total dose. 5 to 10 years old: total dose is 20-35 mcg/kg, maintenance - 25-35% of the total dose. Over 10 years old: total dose is 10-15 mcg/kg, maintenance - 25-35% of the total dose. Side Effects: During the use of the preparation, heart rhythm disturbances (atrioventricular block, ventricular extrasystoles, ventricular tachycardia, atrial fibrillation and flutter), bradycardia may develop. Also possible: nausea, vomiting, loss of appetite, headache, dizziness, collapse, weakness, insomnia, visual disturbances (scotoma or blurred vision), mental disorders, depression, seizures, rarely skin allergic reactions. These symptoms indicate overdose. In children, gastrointestinal side effects are less common than in adults. Heart rhythm disturbances and central nervous system changes are more common. For other side effects, consult your doctor. Contraindications: *Hypersensitivity to the preparation; *Sick sinus syndrome, atrioventricular block of II and III degree; *Ventricular tachycardia and ventricular fibrillation; *Hypokalemia and hypercalcemia; *Electrocardioversion planned within the next 1-2 days; *Hypertrophic cardiomyopathy. Pregnancy and Lactation: During pregnancy, the preparation is used only when the benefit to the mother clearly outweighs the potential risk to the fetus. Digoxin passes into breast milk. Despite its low concentration in breast milk, it is prescribed with caution. The decision to prescribe the preparation during lactation is made by the doctor. Special Instructions: The patient must inform the doctor about existing diseases (e.g., acute myocardial damage, chronic heart and lung failure, history of myocardial infarction, atrial fibrillation, hypothyroidism). In elderly patients with low body weight or renal insufficiency, dose adjustment of the preparation is necessary. Patients taking antibiotics (e.g., macrolides) should inform their doctor, as this increases the bioavailability of digoxin. Rarely, electrolyte imbalance may occur during the use of digoxin, for example, during diarrhea, which leads to an increase in the action of cardiac glycosides. Intravenous administration of calcium salts is not allowed in patients treated with digoxin. Effect of the Preparation on Driving and Operating Machinery: The preparation does not affect concentration. Overdose: In case of overdose, intensification of side effects is observed. Drug Interactions: Intravenous administration of calcium and other agents that reduce serum potassium concentration (hydrochlorothiazide, furosemide, corticosteroids) causes heart rhythm disturbances. Beta-blockers and calcium antagonists, together with digoxin, cause bradycardia. Adrenaline, orciprenaline, salbutamol, and other sympathomimetic amines cause excitation of the sinus node, and in patients treated with digoxin - heart rhythm disturbances. It is not recommended to combine digoxin with preparations that affect calcium metabolism, e.g., parathyroid hormones, their synthetic analogues, or high doses of vitamin D. Amiodarone, quinidine, propafenone, verapamil, indomethacin, and itraconazole increase digoxin concentration in the blood. Peristalsis-inhibiting preparations enhance digoxin absorption. Neutralizing agents: kaolin, neomycin, and cholestyramine suppress digoxin absorption. Patients taking digoxin may experience ECG changes. Storage Conditions and Expiry Date: Store the preparation at room temperature, protected from light and children.