Properties
What is it?
PUROXAN - PUROXAN 100ml. Syrup International Nonproprietary Name - doxofilline Clinical-Pharmacological Group - Bronchodilators; Phosphodiesterase Inhibitors Composition and Dosage Form Tablets 400 mg: 10 and 20 pcs. Syrup 2%: 1 bottle. 1 tablet doxofilline. . . . 400 mg Excipients: colloidal silicon dioxide, wheat starch, mannitol, povidone, microcrystalline cellulose, talc, magnesium stearate. Syrup 2%: 100 ml bottle. Doxofilline. . . . 2 g Excipients: sucrose, sodium saccharin, ammonium glycyrrhizinate, sodium methylparaben, sodium propylparaben, alpine grease, mint flavoring powder, purified water. Pharmacological Properties Doxofilline (7-(1,3-dioxolan-2-methyl) theophylline) is a new type of xanthine-series bronchodilator, which differs from theophylline in that the dioxolane group is located at the seventh position. Like theophylline, the mechanism of action of doxofilline is related to the inhibition of phosphodiesterase. However, unlike theophylline, it has a lower affinity for adenosine A1 and A2 receptors, which increases the safety of the drug. The bronchodilating properties of doxofilline were revealed by clinical observation in patients with bronchial asthma and chronic obstructive pulmonary disease. Doxofilline reduces the number of asthma attacks and the frequency of beta-2 agonist use. Based on safety data, the drug exhibits better tolerability towards the cardiovascular, digestive, and central nervous systems. No correlation was found between doxofilline blood serum levels and any adverse effects. During clinical studies, no sleep disturbances, chronotropic cardiac effects, or increased gastric secretion were observed. See blog: Puroxan - A drug for the treatment of chronic respiratory diseases Indications Puroxan is prescribed for patients with bronchial asthma and chronic obstructive pulmonary disease. Dosage and Administration Tablets in adults: 1 tablet (400 mg) 2 times a day. The dose may be increased up to 1200 mg as prescribed by a doctor. In elderly patients: with cardiovascular, liver, and gastrointestinal diseases, the dose may be reduced to 1/2 tablet 2 times a day. Syrup in children: The recommended daily dose of doxofilline is 12 mg/kg per day in two divided doses. If the result is insufficient, under the supervision of a doctor, the dose can be increased to 18 mg/kg. Syrup in adults: 2 measuring cups = 20 ml (400 mg) 2 times a day. Syrup in the elderly: 1 measuring cup = 10 ml (200 mg) 2 times a day. Side Effects Rarely observed: nausea, vomiting, headache, irritability, insomnia, palpitations, and tachycardia. Contraindications Contraindicated in patients with hypersensitivity to the components of the drug. Pregnancy and Lactation Animal studies have shown that doxofilline does not harm the fetus and reproductive capacity. Nevertheless, its administration during pregnancy is only in cases of extreme necessity. There are no reports of doxofilline use in breastfeeding mothers. Special Instructions The half-life of doxofilline may increase in severe liver and heart failure. Some drugs inhibit the excretion of xanthines (including doxofilline) from the body, for example: erythromycin, troleandomycin, lincomycin (and other antibiotics of this group), allopurinol, cimetidine, propranolol, anti-influenza vaccine. In this case, the dose of doxofilline needs to be reduced. Phenytoin, along with other anticonvulsants, and smoking accelerate the excretion and half-life of doxofilline: the dose may need to be increased. Doxofilline should be administered with caution in patients with gastric or duodenal ulcer disease, or in the elderly with impaired liver function. Overdose Although serious cardiac rhythm disturbances are not proven with doxofilline overdose, their complete exclusion is impossible, as it is a xanthine-series substance. With a significant overdose, seizures may occur, which are its primary symptom. In case of adverse reactions, treatment must be discontinued. Resumption of treatment with reduced doses is permissible only as prescribed by a doctor. Drug Interactions Doxofilline should not be administered with other xanthine derivatives. Cases of toxic synergism of xanthines and ephedrine have been described. Some drugs inhibit the excretion of xanthines (including doxofilline) from the body, for example: erythromycin, troleandomycin, lincomycin (and other antibiotics of this group), allopurinol, cimetidine, ranitidine, propranolol, anti-influenza vaccine. No correlation was found between doxofilline blood serum levels and any adverse effects. Storage Conditions and Shelf Life The preparation should be stored at a temperature not exceeding 25ºC, out of reach of children. Shelf life – 2 years. Dispensing from Pharmacy The preparation is dispensed by prescription only. Manufacturer, Country M&H MANUFACTURING Co, Netherlands
