Properties
What is it?
International Nonproprietary Name - acetylcysteine Clinical-pharmacological group: Pulmonology → Mucolytics and antitussives → Mucolytics and expectorants Composition One tablet contains: Active substance – 600mg acetylcysteine; Excipients: citric acid, sodium bicarbonate, aspartame, lemon flavoring. Description: White tablets with a lemon scent. Indications Respiratory tract diseases with viscous, difficult-to-expectorate sputum secretion: bronchitis, tracheitis, bronchiolitis, pneumonia, bronchiectatic disease, cystic fibrosis, lung abscess, emphysema, laryngotracheitis, interstitial lung disease, atelectasis of the lungs. Catarrhal and purulent otitis, sinusitis, rhinosinusitis (improves secretion discharge), discharge of viscous mucus from the respiratory tract in the post-traumatic and postoperative periods. Dosage and Administration Take orally. For adults: 1 effervescent tablet 600mg dissolved in 1/3 glass of water and taken once a day. The duration of the treatment course is determined individually. For acute diseases, the treatment course is 5-10 days, for chronic diseases - for several months (as recommended by a doctor). Side Effects Rarely: nausea, heartburn, feeling of fullness in the stomach, vomiting, diarrhea, skin rash, itching, urticaria, nosebleeds, tinnitus. Cases of bronchospasm, collapse, stomatitis, and reduced platelet aggregation have also been described with acetylcysteine. Contraindications Hypersensitivity to acetylcysteine, peptic ulcer disease of the stomach and duodenum in the exacerbation stage, children under 18 years of age, lactation period. Pregnancy and Lactation The preparation is prescribed during pregnancy when the expected benefit to the mother outweighs the potential risk of negative effects on the fetus. If the preparation is necessary during lactation, breastfeeding should be discontinued. Special Instructions In bronchial asthma and obstructive bronchitis, acetylcysteine is prescribed under systematic control of bronchial patency. The preparation contains aspartame, therefore it is not recommended for use in phenylketonuria. When dissolving acetylcysteine, glass containers should be used, avoiding contact with rubber and metal surfaces. Prescribe with caution: in peptic ulcer disease of the stomach and duodenum, esophageal varices, bloody sputum, pulmonary hemorrhage, phenylketonuria, bronchial asthma, adrenal gland disease, renal and hepatic insufficiency, arterial hypertension. Overdose Administration of acetylcysteine at a dose of 500mg/kg/day does not cause symptoms of overdose.
