Properties
- Form
- tableti
- Dosage mg
- 1000
- Pack
- 100
What is it?
International Nonproprietary Name - metformin Composition One tablet contains: Core: Active ingredient: metformin hydrochloride - 500/850/1000mg; Excipients: povidone 20/30/40 mg, magnesium stearate 5.0/8.5/10.5 mg. Clinical - Pharmacological Group: Oral hypoglycemic preparation. Pharmacological - Therapeutic Group: Oral hypoglycemic agent of the biguanide group. Dosage Regimen The dose of the preparation is determined individually by the doctor according to the blood glucose level. The initial dose is 500-1000 mg/day (1-2 tablets). After 10-15 days, a further gradual increase in dose is possible, taking into account the blood glucose level. The maintenance dose of the preparation is usually 1500-2000 mg/day (3-4 tablets). The maximum dose is 3000 mg/day (6 tablets). In elderly patients, the recommended daily dose should not exceed 1 g (2 tablets). Metformin tablets should be taken whole, without crushing, during or immediately after meals, with a small amount of liquid (1 glass of water). To reduce gastrointestinal side effects, the daily dose should be divided into 2-3 administrations. Given the increased risk of lactic acidosis development, the dose of the preparation must be reduced in cases of severe metabolic disorders. Side Effects Gastrointestinal system: nausea, vomiting, metallic taste in the mouth, loss of appetite, diarrhea, bloating, abdominal pain. These symptoms are particularly common at the beginning of treatment and usually disappear on their own. The mentioned symptoms can be reduced by prescribing antacids, atropine derivatives, or antispasmodics. Metabolism: in rare cases, lactic acidosis (requires discontinuation of treatment); in case of long-term treatment, hypovitaminosis B12 (impaired absorption). Hematopoietic organs: in isolated cases - megaloblastic anemia. Endocrine system: hypoglycemia. Allergic reactions: skin rash. Contraindications - Diabetic ketoacidosis, pre-coma, coma; - Impaired renal function; - Acute conditions with a risk of impaired renal function (diarrhea, vomiting), fever, severe infectious diseases, hypoxic conditions (shock, sepsis, kidney infections, bronchopulmonary diseases); - Clinically manifested acute and chronic diseases that can lead to tissue hypoxia (acute myocardial infarction, heart or respiratory failure); - Serious surgical operations and trauma (when insulin therapy is indicated); - Impaired renal function; - Chronic alcoholism, acute alcohol poisoning; - Contraindicated for use of the preparation for at least 2 days before and 2 days after radioisotope and X-ray examinations using iodine-containing contrast media; - Lactic acidosis (including in history); - Hypocaloric diet (less than 1000 calories per day); - Pregnancy; - Lactation; - Hypersensitivity to the preparation; - Not recommended for individuals over 60 years of age who perform heavy physical labor, due to the risk of developing lactic acidosis. Use of the preparation during pregnancy and lactation For planning pregnancy, as well as during pregnancy while taking metformin, the preparation should be discontinued and insulin therapy prescribed. Given that there is no data on the penetration of the preparation into breast milk, its use during lactation is contraindicated. If metformin use is necessary during lactation, breastfeeding should be discontinued.
