Properties
What is it?
International Nonproprietary Name - citicoline Clinical-pharmacological group: Central Nervous System → Agents Improving Brain Metabolism → Nootropic Preparations Composition 1 ampoule of the preparation contains: Active substance: citicoline (as sodium salt) 500 mg or 1000 mg. Excipients: sodium hydroxide and/or hydrochloric acid, water for injection Pharmacotherapeutic group Psychostimulants and nootropic preparations. Indications for use - Acute period of ischemic stroke; - Recovery period of ischemic and hemorrhagic stroke; - Traumatic brain injury, acute and recovery period; - Cognitive disorders in degenerative and vascular diseases of the brain. Method of administration and dosage Solution for intravenous and intramuscular administration. Intravenously administered as a slow intravenous injection (over 5 minutes) or by drip infusion (40-60 drops per minute). Intravenous administration is more effective than intramuscular. When administered intramuscularly, repeated injection of the preparation into the same site is not recommended. Acute period of ischemic stroke and traumatic brain injury: the recommended dose is 1000 mg every 12 hours from the first day of diagnosis; duration of treatment - at least 6 weeks. 3-7 days after the start of treatment, it is possible to switch to intramuscular (1-2 injections per day) or oral administration (if swallowing function is not impaired). Recovery period of ischemic and hemorrhagic stroke, traumatic brain injury, cognitive disorders in degenerative and vascular diseases of the brain: the recommended dose is 500-2000 mg per day. The dose and duration of treatment depend on the severity of the disease symptoms. In case of prolonged consciousness disorders, continuous use of the preparation from the initial stage of the disease is possible. Elderly patients do not require dose adjustment when Ronocit is administered intravenously or intramuscularly. The solution for intravenous or intramuscular administration is intended for single use. The preparation is compatible with all types of intravenous isotonic solutions and dextrose solutions. Contraindications - Hypersensitivity to the components of the preparation. - Vagotonia (increased tone of the parasympathetic part of the autonomic nervous system). Side effects Frequency of side effects is determined as follows: very rarely (< 1/10000) Central and peripheral nervous system: very rarely - insomnia, headache, dizziness, excitability, tremor, numbness of paralyzed limbs. Gastrointestinal system: very rarely - nausea, decreased appetite, changes in liver enzyme activity. Allergic reactions: very rarely - rash, itching, anaphylactic shock. Other: very rarely - fever; in isolated cases, short-term hypotensive effect, stimulation of the parasympathetic nervous system. Special instructions In case of traumatic brain injury, it is necessary to administer preparations such as mannitol and corticosteroids to reduce intracranial pressure. In case of intracranial hemorrhage, the dose of 500 mg citicoline should not be exceeded in a single administration; in such cases, the dose can be divided (100-200 mg 2-3 times a day). Effect on ability to drive and operate machinery During treatment, caution should be exercised when driving a car and performing tasks that require speed of psychomotor reactions. Use during pregnancy and lactation During pregnancy, administration of the preparation is recommended only if the expected benefit to the mother outweighs the potential risk to the newborn. When administering the preparation during lactation, the issue of discontinuing breastfeeding should be considered.