Properties
What is it?
COLIN (COLIN) General Description: International Nonproprietary Name: Simethicone; Main Physical-Chemical Properties: Capsule: Opaque, hard gelatin capsule with a white body and blue cap, filled with white or yellowish-white powder; Suspension: Orange sweet suspension with a fragrant odor. Composition 1 capsule contains: Simethicone – 40 mg. Excipients: Colloidal silicon dioxide, croscarmellose sodium, magnesium stearate, magnesium hydroxide. Capsule shell composition: Gelatin, methylparaben, propylparaben, sodium lauryl sulfate, colorants: titanium dioxide (E 171), Brilliant Blue FCF (E 133), purified water. 1 ml of suspension contains: Simethicone emulsion, equivalent to 40 mg simethicone. Excipients: Sodium saccharin, sodium carmellose, sodium benzoate, disodium edetate, liquid sorbitol, citric acid monohydrate, anise oil, Avicel RC–591 mixture (microcrystalline cellulose and sodium carboxymethylcellulose), Sunset Yellow FCF colorant (E 110), glycerin, purified water. See blog: COLIN — an anti-bloating medicine for people of all ages. Dosage Form: Capsule, 40 mg. Oral suspension, 30 ml. Pharmacological Group: Other drugs for functional gastrointestinal disorders. ATC Code: A03AX13. Pharmacological Properties: COLIN is an anti-flatulence agent. It reduces the surface tension of gas bubbles in the gastrointestinal tract mucus and chyme, inhibits their formation, and promotes their breakdown. The released gas bubbles are absorbed by the intestinal wall mucosa or excreted unchanged through intestinal peristalsis. As a result, the total amount of gas and pressure in the intestinal lumen decreases. Additionally, simethicone forms a protective layer on the gastrointestinal mucosa, protecting it from aggressive factors. During ultrasound and X-ray examinations of the gastrointestinal tract, simethicone prevents image artifacts caused by gas bubbles and foam in the digestive tract. Pharmacokinetics: Simethicone is chemically inert and is not absorbed from the gastrointestinal tract. It is excreted unchanged after passing through the digestive system. Indications: - Excessive gas production and accumulation in the gastrointestinal tract (meteorism, dyspepsia, abdominal bloating, aerophagia, Remheld's syndrome, gas formation in the postoperative period); - Pre-preparation period for abdominal and pelvic organ examinations using X-ray, ultrasound, and instrumental methods; - Poisoning with surfactants, synthetic detergents. Dosage and Administration: COLIN is taken orally during or after meals, if necessary, before bedtime. Adults and children over 6 years of age are prescribed 1-2 capsules or 25-50 drops 3-5 times a day. Infants and children under 6 years of age are given 10-15 drops 2-3 times a day during or after meals. Shake the suspension before use! For diagnostic examinations: Take 2 capsules 3 times a day the day before the examination, and 2 capsules in the morning on the day of the examination on an empty stomach, or 50 drops 3 times a day for 2 days before the examination, 50 drops on an empty stomach in the morning on the day of the examination, and 50 drops immediately before the examination. In case of poisoning with synthetic detergents, the dose of COLIN is determined by the severity of intoxication (not less than 320 mg). Side Effects: Allergic reactions: itching, rash (in isolated cases). If any side effect not listed in the instructions for use occurs, the patient should consult a doctor. Contraindications: Hypersensitivity to any component of the preparation, intestinal obstruction, obstructive diseases of the gastrointestinal tract. Interactions with other drugs and other types of interactions: Prolonged use of the preparation in high doses with antacids is not recommended. Overdose: No cases of overdose have been reported. Pregnancy and lactation: COLIN can be used during pregnancy and breastfeeding on the recommendation of a doctor. Due to the absence of absorption in the gastrointestinal tract, adverse effects on the fetus and transfer into breast milk are not expected. Special Instructions: COLIN suspension does not contain sucrose, therefore it can be used by patients with diabetes mellitus or digestive disorders. Effect on ability to drive and operate machinery: The preparation does not affect the ability to drive vehicles and operate machinery. Packaging: 10 capsules in a blister, 3 blisters in a cardboard box. 30 ml suspension in an orange polymer bottle, one bottle with a dropper in a cardboard box. Storage Conditions: Capsule: Store at a temperature not exceeding 25°C, in a dry, protected from light, and inaccessible place for children. Suspension: Store at a temperature not exceeding 30°C, protected from light, and inaccessible place for children. After opening the bottle, the suspension is suitable for use for 30 days. The preparation is not allowed to be taken if any defect is found during visual inspection. Shelf Life: Capsule: 2 years. Suspension: 3 years. The preparation is not allowed to be used after the expiry date indicated on the packaging. Dispensing Regime: Pharmaceutical product group III, available without a prescription
