Properties
- Form
- tableti
- Dosage mg
- 10
- Pack
- 30
What is it?
International Nonproprietary Name - amlodipine Clinical-pharmacological group: Cardiovascular system → Antihypertensives → Calcium channel blockers Composition 1 tablet contains the active substance amlodipine maleate, calculated as 5 mg or 10 mg of amlodipine. Excipients: microcrystalline cellulose, pregelatinized starch, sodium starch glycolate, colloidal anhydrous silica, magnesium stearate. Description Round, biconvex white tablets with beveled edges and a score line on one side. Pharmacotherapeutic group Dihydropyridine derivative - "slow" calcium channel blocker. ATC code: C08CA01 Indications • Arterial hypertension (monotherapy or in combination with other antihypertensive agents) • Stable and vasospastic angina (Prinzmetal's angina). Dosage and administration Orally, the initial dose for the treatment of arterial hypertension and angina pectoris is 5 mg of the preparation once a day, regardless of food intake. The dose can be maximally increased to 10 mg once a day. For arterial hypertension, the maintenance dose can be 2.5-5 mg per day. For exertional angina and vasospastic angina - 5-10 mg per day, once. For the prevention of angina attacks - 10 mg/day. For thin patients, patients of medium height, elderly patients, patients with impaired liver function, as a hypotensive agent, Tenox is prescribed at an initial dose of 2.5 mg, as an antianginal agent - 5 mg. No dose adjustment is required when co-administered with thiazide diuretics, beta-blockers, and angiotensin-converting enzyme inhibitors. No dose adjustment is required in patients with liver failure. A dose of 2.5 mg can be obtained by splitting a 5 mg Tenox tablet in half. Contraindications • Hypersensitivity to amlodipine and other dihydropyridine derivatives; • Severe arterial hypotension; • Collapse, cardiogenic shock; • Pregnancy and lactation; • Age up to 18 years (efficacy and safety have not been established). With caution: impaired liver function, sick sinus syndrome (marked bradycardia, tachycardia), decompensated chronic heart failure, mild or moderate arterial hypotension, aortic stenosis, mitral stenosis, hypertrophic obstructive cardiomyopathy, acute myocardial infarction (and within 1 month after), diabetes mellitus, lipid profile disorders, elderly age.
