Properties
What is it?
Composition Rectal suppositories contain Active substance: Tenoxicam 20 mg. Excipient: Vitepsol H 15. ATC code of the preparation: M01AC02 Pharmacotherapeutic group Non-steroidal anti-inflammatory drugs. Oxicams. Pharmacological properties Artoxan is an effective non-steroidal anti-inflammatory drug (NSAID) with potent anti-inflammatory, analgesic, and less pronounced antipyretic effects. The drug's properties are due to the inhibition of both isoforms of the enzyme cyclooxygenase, which leads to a disruption of arachidonic acid metabolism and blockade of prostaglandin synthesis. The anti-inflammatory effect of Artoxan is due to reduced capillary permeability (limits exudation), stabilization of lysosomal membranes (prevents the release of tissue-damaging lysosomal enzymes), suppression or inactivation of the synthesis of inflammatory mediators (prostaglandins, histamine, bradykinin, lymphokines, complement factors). The drug reduces the amount of free radicals at the site of inflammation, reduces chemotaxis and phagocytosis; inhibits the development of the proliferative phase of inflammation; reduces post-inflammatory tissue sclerosis. Indications for use Inflammatory-degenerative diseases of the musculoskeletal system with accompanying pain syndrome: - Joint syndrome in gout, rheumatoid arthritis, osteoarthritis, ankylosing spondylitis, osteochondrosis, articular form of rheumatism (periarthritis, tendinitis, bursitis, myositis), gout; - Back pain, neuralgia, myalgia, sciatica, lumbago; - Dysmenorrhea; - In case of trauma, burns. Contraindications - Hypersensitivity to tenoxicam or other NSAIDs; - Erosive-ulcerative lesions of the digestive system; - Gastrointestinal bleeding; - Aspirin triad (accompanied by bronchial asthma); - Severe liver and kidney disorders; - Diabetes mellitus; - Arterial hypertension, heart failure, edema; - Pregnancy, lactation period; - Blood diseases