Properties
What is it?
Composition and Dosage Form 1 vial contains 1,000,000 IU of sterile Benzylpenicillin sodium salt. Indications Infectious and inflammatory diseases caused by microorganisms sensitive to the drug: - Respiratory tract infections (croupous and focal pneumonia, purulent pleurisy); - Ear, nose, and throat infections (tonsillitis, scarlet fever, diphtheria); - Sepsis; - Septic endocarditis; - CNS infections (meningitis); - Inflammatory eye diseases (blennorrhea); - Intra-abdominal infections (peritonitis); - Genitourinary tract infections (cystitis, urethritis, gonorrhea, syphilis); - Purulent infections of skin and soft tissues (erysipelas, infected wounds); - Osteomyelitis; - Biliary tract infections; - Anthrax. Dosage and Administration The drug is administered intramuscularly, intravenously, subcutaneously, intralumbarly, and into the abdominal and pleural cavities. For adults, the daily dose is 250,000 - 600,000 IU. For moderate infections, a single dose is 250,000 - 500,000 IU, with a daily dose of 1,000,000 - 2,000,000 IU. For severe infections, the daily dose is 1,000,000 - 2,000,000 IU. For gas gangrene, 4,000,000 - 6,000,000 IU. For children under 1 year of age, the daily dose is 50,000 - 100,000 IU/kg of body weight. For children over 1 year of age, the daily dose is 50,000 IU/kg of body weight. If necessary, the daily dose can be increased to 200,000 - 300,000 IU/kg of body weight, and up to 500,000 IU/kg of body weight in life-threatening cases. The drug is administered 4-6 times a day. Benzylpenicillin solutions are prepared extemporaneously. For intramuscular injection, add 1-3 ml of sterile water for injection, or 0.9% sodium chloride solution, or 0.5% Novocaine solution to the vial contents. For bolus intravenous injection, a single dose of 1,000,000 - 2,000,000 IU is dissolved in 5-10 ml of water for injection or isotonic sodium chloride solution and administered slowly over 3-5 minutes. For intravenous infusion (60-80 drops per minute), 2,000,000 - 5,000,000 IU of antibiotic is dissolved in 100-200 ml of 0.9% sodium chloride or 5% glucose solution. Intravenous administration is performed 1-2 times a day, in combination with intramuscular injections. For adults, 10,000 - 20,000 IU of the drug per 1 ml is administered into the abdominal or pleural cavity. For children, 2,000 - 5,000 IU per 1 ml. The drug is dissolved in water for injection or 0.9% sodium chloride solution. The course of treatment is 5-7 days, after which intramuscular administration is resumed. Intralumbar administration is indicated for purulent diseases of the brain and spinal cord, as well as their meninges. For adults, the dose is 5,000 - 10,000 IU. For children, 2,000 - 5,000 IU. Administered slowly at 1 ml per minute, once a day. The drug is dissolved in water for injection or 0.9% sodium chloride solution at a concentration of 1,000 IU per 1 ml. Before injection, 5-10 ml of cerebrospinal fluid is withdrawn from the cerebrospinal canal and added to the same amount of antibiotic solution. Injections are repeated for 2-3 days, after which intramuscular administration is resumed. Syphilis and gonorrhea are treated according to specific regimens. Depending on the form and severity of the disease, the drug is administered for 7-10 days up to 2 months or longer (e.g., sepsis, septic endocarditis). Contraindications Hypersensitivity to β-lactam antibiotics. Bronchial asthma, urticaria, and other allergic diseases. Intralumbar administration is contraindicated in epilepsy. Pregnancy and Lactation The use of the drug during pregnancy is permissible when the expected benefit to the mother clearly outweighs the potential risk of adverse effects on the fetus. If the drug is necessary during lactation, breastfeeding should be discontinued. Storage Conditions and Shelf Life Store in a dry place at room temperature. Keep out of reach of children. Shelf life: 3 years. Do not use the drug after the expiry date indicated on the packaging. Dispensing Regulations By prescription (Group II).
