Properties
What is it?
Composition: 100g of granulated powder contains: Citric acid anhydrous 39.90g Sodium citrate anhydrous 27.85g Potassium hydrogen carbonate 32.25g Dosage form: Granulated powder Clinical-pharmacological group: Urolitholytic agent Pharmacological properties: The action of the preparation is due to the sequential neutralization of urine reaction. When the urine reaction approaches neutral and the pH is 6.6-6.8, the solubility of uric acid salts significantly increases and potassium excretion is prolonged. If this pH value is maintained for a long time, it leads to the dissolution of uric acid concretions and prevents their formation. In addition, Blemaren reduces calcium elimination, improves the dissolution of calcium oxalate in urine, inhibits crystal formation, and prevents the formation of calcium oxalate concretions. Indications: - Dissolution and prevention of formation of uric acid and calcium-oxalate concretions. - Dissolution of mixed uric acid-oxalate concretions containing up to 25% oxalates. - Alkalinization of urine in patients receiving cytostatic agents or drugs that cause uric acid excretion. - Symptomatic treatment of skin porphyria (Porphyria cutanea tarda). Contraindications: - Acute and chronic renal failure. - Acid-base imbalance (metabolic alkalosis). - Chronic infectious diseases of the urinary tract caused by urea-splitting bacteria. - Strict salt-free diet (e.g., severe form of hypertension). - Pregnancy and lactation (since data on the use of the preparation during these periods are not available, its use is not recommended). Dosage regimen: The dosage of the preparation should be such that the urine pH value is 6.2-6.8. The average daily dose varies depending on individual characteristics and ranges from 6g to 18g. The preparation is administered at equal intervals 2-3 times a day (e.g., 08:00; 14:00; 20:00) in a dose of 1-2 measuring spoons. If the pH is less than 6.2, the dose of the preparation is increased until it reaches 6.8. If the preparation is prescribed for the dissolution of cystine stones, the urine pH should be 7.5-8.5. In this case, the dose of the preparation is increased. For the dissolution of uric acid stones, the urine pH value should be 6.8-7.4. For the prevention of calcium-oxalate stone formation, the urine pH value should be 7.0, and during the treatment of porphyria - 7.2-7.5. The duration of treatment ranges from 4 weeks to 6 months. The granules are dissolved in liquid (tea, fruit juice, alkaline mineral water). Efficacy control is carried out 3 times a day, before taking each single dose, the urine pH value is determined with an indicator. The color obtained on the paper is compared with the scale for 2 minutes, and the obtained value is recorded in the control calendar. For monitoring efficacy in the presence of cystine stones and during the treatment of porphyria, special indicator paper with a urine pH range of 7.2 to 9.7 is required. Storage conditions and shelf life: The preparation should be stored at a temperature not exceeding 250C, in a place protected from children. Shelf life - 3 years. The use of expired preparation is prohibited.