Properties
What is it?
International Nonproprietary Name - cefdinir Clinical-pharmacological group: Antibacterial agents → Beta-lactam antibiotics (penicillins and cephalosporins) → Cephalosporins → Third-generation cephalosporins Composition and dosage form 1 tab. cefdinir......300 mg Clinical-pharmacological group Third-generation cephalosporin. Indications Cefdinir is indicated for the treatment of the following bacterial infections: - Acute bacterial otitis media: caused by Haemophilus influenzae (including beta-lactamase producing strains), Streptococcus pneumoniae (penicillin-susceptible strains only) and Moraxella catarrhalis (including beta-lactamase producing strains); - Acute maxillary sinusitis: caused by Haemophilus influenzae (including beta-lactamase producing strains), Streptococcus pneumoniae (penicillin-susceptible strains only) and Moraxella catarrhalis (including beta-lactamase producing strains); - Acute bacterial rhinosinusitis: caused by Haemophilus influenzae (including beta-lactamase producing strains), Streptococcus pneumoniae (penicillin-susceptible strains only) and Moraxella catarrhalis (including beta-lactamase producing strains); - Pharyngitis/tonsillitis: caused by Streptococcus pyogenes; - Uncomplicated skin infections: caused by Staphylococcus aureus (including beta-lactamase producing strains) and Streptococcus pyogenes. Dosage regimen The total daily dose for all infections is 14 mg/kg up to a maximum dose of 600 mg per day. A single daily dose for 10 days is as effective as twice daily dosing. Single daily dosing has not been studied for skin infections, so in this case, cefdinir oral suspension should be taken twice daily. Cefdinir oral suspension can be taken independently of food. Use in patients with renal impairment: In adult patients with creatinine clearance <30 mL/min, the dose is 300 mg once daily. Hemodialysis removes cefdinir from the body. The recommended starting dose is 300 mg (or 7 mg/kg) every other day. After each hemodialysis procedure, 300 mg (or 7 mg/kg) is administered. Subsequent doses are 300 mg (or 7 mg/kg) every other day. Side effects Side effects after cefdinir use are mild and self-limiting. The most frequently observed side effects are diarrhea, vaginal candidiasis, nausea, headache, abdominal pain, and vaginitis. In case of unexpected side effects, consult your doctor. Contraindications The drug is contraindicated in patients with hypersensitivity to antibiotics of the cephalosporin group.