Properties
What is it?
Cistibacti ® orally dispersible powder stick 2g 15 sticks per pack Cistibacti® is a food supplement with Cysti-Complex ®. The complex contains D-mannose, bearberry and cranberry extracts, beta-glucans, and palmitoylethanolamide (PEA). Ingredients: Cysti-Complex ® (D-mannose, bearberry Arctostaphylos uva-ursi L. leaf dry extract tit. 20% arbutin, cranberry Vaccinium macrocarpum Aiton fruit dry extract tit. 40% proanthocyanidins, beta-glucan, PEA (palmitoylethanolamide)); anti-caking agent: silicon dioxide; sweeteners: erythritol, sucralose; flavorings. Active ingredient content per 1 stick: Cysti-Complex ® 533 mg D-mannose 200 mg bearberry Arctostaphylos uva-ursi L. leaf dry extract tit. 20% arbutin 167 mg 33.5 mg cranberry Vaccinium macrocarpum Aiton fruit dry extract tit. 40% proanthocyanidins 133 mg 53 mg beta-glucan 33 mg PEA (palmitoylethanolamide) 60 mg Product indication and mechanism: Cistibacti® is a food supplement intended for the prevention of urinary tract infections and for maintaining the normal function of the urinary system. Its Cysti-Complex ® creates a protective barrier in the urinary system to prevent the development of new infections or their recurrence. This product is a natural origin, antibiotic-sparing strategy aimed at reducing the risk of developing antibiotic resistance. D-mannose is a simple sugar of natural origin. After oral administration, most of it is excreted unchanged in the urine. It mimics the receptors required for uropathogens to attach to urothelial cells of the host organism. D-mannose competitively binds to bacterial surface ligands, reduces the number of bacteria attached to mucous membranes, and shifts the balance of host-pathogen interaction in favor of the host. Cranberry fruit extract is a natural bacteriostatic and anti-inflammatory agent. It inhibits the adhesion of uropathogens to urothelial cells through several mechanisms. Specifically, proanthocyanidins in cranberry extract inhibit the adhesion of uropathogenic E. coli mediated by P-fimbriae, while fructose inhibits adhesion mediated by type-1 fimbriae. Type-1 fimbriae of uropathogenic E. coli are responsible for infection persistence, enhancement of inflammatory response, and ascending spread of bacteria by disrupting the contractility of the urinary tract. P-fimbriae ensure the adhesion of uropathogens to the surface of the upper urinary tract and kidney cells; they are responsible for the development of complicated infections. The main antimicrobial component of bearberry leaf extract, arbutin, modifies the bacterial cell wall and significantly reduces pathogen adhesion to the urothelium. It stimulates diuresis (without affecting sodium and potassium excretion) and exhibits anti-inflammatory action. Beta-glucans are polysaccharides that form the cell wall of some bacteria and fungi. They bind to specific receptors on the cell surface and enhance the body's immune defense by stimulating the activity of the complement system, macrophages, and natural killer cells. Palmitoylethanolamide (PEA) is an endogenous substance of the endocannabinoid family, produced in tissues in response to inflammatory stimuli. It performs a protective function and promotes cell regeneration. Areas of the central nervous system responsible for pain control are rich in cannabinoid receptors. Their stimulation activates pain reduction mechanisms. PEA exhibits analgesic effects by selectively acting on CB2 receptors. It also has anti-inflammatory action at the peripheral level by inhibiting the degranulation of mast cells. Dosage: Take 1-2 sticks per day. The contents of the stick are taken directly, without water. If desired, it can be taken dissolved in water. Warnings: Keep out of reach of children under 3 years of age. Do not exceed the recommended daily dose. Food supplements are not intended to replace a varied and balanced diet or a healthy lifestyle. Storage conditions: Store in a cool, dry place, away from heat sources. Shelf life refers to the product in an unopened package, stored correctly. Do not use after the expiry date indicated on the packaging.