Activamente 14 sacheti

Form

pudra

Pack

14

Activament Food Supplement 10 ml Oral Solution in Sachet N14 Composition Active Ingredients Per Sachet Citicoline 250 mg Vitamin B6 1.4 mg Vitamin B12 2.5 mcg Other Ingredients: Water, Coloring: E150b; Cola Flavor, Acidity Regulator: Citric Acid; Preservatives: Potassium Sorbate, Sodium Benzoate; Sweetener: Sucralose. Pharmacological Action Pharmacodynamics Exogenous intake of citicoline increases the pool of choline available for biosynthetic pathways. It reduces glutamate levels and increases ATP. It protects against neurotoxic damage caused by ischemia. It improves glucose metabolism and brain blood supply. It increases the availability of neurotransmitters (acetylcholine, norepinephrine, dopamine). Citicoline stimulates the dopaminergic system in the brain and retina. As a result, it increases the level of retinal neurotransmitter (dopamine). It improves the function of retinal and postretinal visual pathways in amblyopia. Chronic intake of citicoline increases the density of dopamine receptors and contributes to the partial restoration of function (which normally decreases with age). It stimulates glutathione synthesis, promotes sphingomyelin storage, and improves signal transduction in nerve cells and the retina. Vitamins B6 and B12 ensure nerve cell energy metabolism and myelination. They lower homocysteine levels. They improve neurotransmission and cognitive function. Pharmacokinetics After oral administration, citicoline is well absorbed. Absorption is almost complete and bioavailability is equivalent to parenteral administration. It is metabolized in the intestine and liver into choline and cytidine. It is well distributed in brain structures. The choline fraction is rapidly incorporated into structural phospholipids, the cytidine fraction into cytidine nucleotides and nucleic acids. Only a small part of the dose (<3%) is excreted in urine and feces. Approximately 12% of the administered dose is excreted as exhaled carbon dioxide. Use Activament is a food supplement for the normal functioning of the nervous system. It is taken to improve concentration, focus, learning, and memory in children, adults, and the elderly. Taking Activament is effective in the following conditions: • Attention Deficit Hyperactivity Disorder • Post-surgical recovery period • Cognitive impairment, in cases of age-related or degenerative and vascular diseases of the brain • Recovery period from ischemic and hemorrhagic stroke • Post-traumatic recovery period from head injury • Diabetic neuropathy, retinopathy • Glaucoma • Amblyopia • Adjuvant therapy for depression Dosage and Administration Recommended dose is 1-2 sachets per day. It is advisable to shake the sachet before opening to homogenize the contents. Contraindications Hypersensitivity to citicoline or any component of the formulation. Use during pregnancy Data on the use of citicoline during pregnancy are not available. Use in children Adequate oral intake of citicoline is considered safe for children from 1 year to 13 years of age. Interactions Citicoline enhances the effect of medications containing levodopa. It should not be taken with medications containing meclofenoxate. Storage Conditions Store in a dry, cool, dark place at temperatures between 12 - 25° C. Shelf life applies to unopened product stored under conditions. Precautions Keep out of reach of children under 3 years of age. Do not exceed the recommended dose. Food supplements do not replace a varied balanced diet and a healthy lifestyle. Do not use if the packaging is damaged.