Properties
What is it?
International Nonproprietary Name - escitalopram Clinical-pharmacological group: Central Nervous System → Antidepressants → Selective Serotonin Reuptake Inhibitors Composition and Dosage Form Oral drops: 15 ml bottle 1 ml - escitalopram . . . . . . . 10 mg (20 drops) Clinical-pharmacological group Antidepressant, SSRI Indications Used in the treatment of the following conditions: - Major depressive disorder; - Panic disorder with or without agoraphobia; - Social anxiety disorder. Administration and Dosage of Oral Drops: The preparation is taken once a day, it can be taken at any time of the day, regardless of food intake. Its safety has not been established for daily doses higher than 20 mg (40 drops). Major depressive disorder: Usually taken 10 mg (20 drops) once a day, the daily dose can be increased up to 20 mg (40 drops) according to the patient's individual needs and the severity of depression. The antidepressant effect is usually achieved in 2-4 weeks. Antidepressant treatment is symptomatic, so the preparation should be used for relapse prophylaxis for 6 months or more. Anxiety disorder with and without agoraphobia: Treatment with escitalopram starts with 5 mg (10 drops) per day for the first week and usually increases to 10 mg (20 drops) per day. Later, the daily dose can be increased up to 20 mg (40 drops) per day according to the patient's individual needs. Maximum effect is achieved in 3 months. Treatment lasts for several months. Social anxiety disorder (social phobia): Usually prescribed 10 mg (20 drops) per day. A treatment period of 2-4 weeks is required to relieve symptoms. Depending on the patient's individual needs, the dose can be reduced to 5 mg (10 drops) or increased to the maximum recommended dose of 20 mg (40 drops). Social anxiety disorder is a chronic condition and it is recommended to assess the patient's response after 12 weeks of treatment. It should be used for relapse prophylaxis for 6 months or more. The effectiveness of treatment should be reviewed at regular intervals. Social anxiety disorder is a well-defined diagnostic terminology for a specific disorder and should not be confused with hyperthymia. Treatment with the preparation is prescribed only if the disease significantly affects professional and social activities. Treatment with the preparation has not been studied in general cognitive behavioral therapy. Treatment with the preparation is part of a complete therapeutic strategy. Generalized anxiety disorder: Usually prescribed 10 mg (20 drops) per day. Depending on the patient's individual needs, the dose can be increased to a maximum of 20 mg (40 drops). Generalized anxiety disorder is a chronically progressing disease and long-term treatment is recommended for relapse prevention. Elderly patients (>65 years): At the initial stage of treatment, half of the recommended dose is prescribed, and for maintenance therapy - the lowest maximum dose. Children and adolescents (<18 years): The use of the preparation in children is not recommended, as its safety and efficacy in this population are unknown. Renal insufficiency: Dose adjustment is not necessary in mild and moderate renal insufficiency. There is no information on severe renal insufficiency (creatinine clearance < 30 ml/min). Liver dysfunction A starting dose of 5 mg (10 drops) is recommended for the first two weeks of treatment. Then the daily dose can be increased up to 10 mg (20 drops) according to the patient's individual needs. Patients with poor CYP2C19 metabolism: In patients with poor CYP2C19 metabolism, a starting dose of 5 mg (10 drops) is recommended for the first two weeks of treatment.