Properties
What is it?
International Nonproprietary Name - Famotidinum Composition One film-coated tablet contains the active substance famotidine 20mg or 40mg. Excipients: corn starch, microcrystalline cellulose, silicon dioxide, talc, magnesium stearate, croscarmellose sodium. Coating: hypromellose, macrogol 6000, titanium dioxide E 171, talc, iron oxide brown colorant. Pharmacotherapeutic group Gastric secretion reducing agent - H2 histamine receptor blocker. Indications • Peptic ulcer disease of the stomach and duodenum, prevention of relapses; • Erosive gastroduodenitis; • Functional dyspepsia, dependent on increased secretion function; • Symptomatic and stress ulcers of the gastrointestinal tract; • Reflux esophagitis; • Prevention of relapses associated with prolonged intake of non-steroidal anti-inflammatory drugs. • Zollinger-Ellison syndrome; • Systemic mastocytosis; • Polyendocrine adenomatosis; • Prevention of relapse of bleeding in the postoperative period. • Prophylaxis of gastric juice aspiration in patients undergoing surgery under general anesthesia (Mendelson's syndrome); • Prophylaxis of aspiration pneumonia; • Dyspepsia with epigastric or chest pain that occurs at night or is associated with food intake. Contraindications Pregnancy, lactation, hypersensitivity to famotidine or other H2 histamine receptor blockers. With caution: renal and/or hepatic insufficiency, liver cirrhosis with portosystemic encephalopathy (in history), immunodeficiency, childhood, pregnancy, lactation. Use during pregnancy and lactation Use during pregnancy and lactation is contraindicated. Method of administration and dosage Orally, without chewing, with a small amount of liquid. For peptic ulcer disease of the stomach and duodenum in the exacerbation phase, symptomatic ulcers, erosive gastroduodenitis, usually 20mg 2 times a day or 40mg once a day at night. If necessary, the daily dose can be increased to 80-160mg. The course of treatment is 4-8 weeks. For dyspepsia associated with increased gastric secretory function, 20mg is prescribed 1-2 times a day. For the prevention of peptic ulcer disease relapse, 20mg is prescribed once a day before bedtime. For reflux esophagitis, 20-40mg 2 times a day for 6-12 weeks. For Zollinger-Ellison syndrome, the dose of the drug and the duration of treatment are determined individually. The initial dose is usually 20mg every 6 hours and can be increased to 160mg every 6 hours. For the prophylaxis of gastric juice aspiration under general anesthesia, 40mg is prescribed in the evening and/or morning before surgery. Famotidine tablets should be swallowed whole without chewing, with a sufficient amount of water. In renal insufficiency, if creatinine clearance is greater than 30ml/min or serum creatinine is greater than 3mg/100ml, the daily dose of the drug must be reduced to 20mg. Side effects • Dry mouth, nausea, vomiting, abdominal pain, flatulence, constipation, diarrhea, loss of appetite; • Increased activity of "liver" enzymes, hepatitis, acute pancreatitis; • Headache, dizziness, insomnia, anxiety, tinnitus; • Rapid fatigue, drowsiness, depression, nervousness, psychosis; • Blurred vision, paralysis of accommodation; • Clouding of consciousness, hallucinations, hyperthermia; • Fever; • Bradycardia, arrhythmia, vasculitis, decreased blood pressure, atrioventricular block. • Muscle pain, joint pain; • Dry skin, alopecia, acne vulgaris, skin rash, itching, bronchospasm, angioneurotic edema, anaphylactic shock, other manifestations of hypersensitivity; • Increased blood urea, leukopenia, thrombocytopenia, agranulocytosis, pancytopenia, bone marrow hypoplasia, aplasia. • With prolonged intake of large doses - hyperprolactinemia, gynecomastia, amenorrhea, decreased libido, impotence.
