Properties
What is it?
AMS-GRAVIDA FERRUM 3-valent iron 100 mg. Supports cardiovascular health. Boosts immunity. Restores iron deficiency. Additional information: Dosage form: Capsules / Container of 90 capsules. Capsule composition includes: Iron (ferrous fumarate) 100 mg 555% Daily Value. Vitamin C (ascorbic acid) 60 mg 167% Daily Value. Folic acid 400 mcg 100% Daily Value. Other ingredients: Cellulose; Gelatin (capsule); Silicon dioxide; Magnesium stearate. Iron deficiency is the most common nutritional deficiency during pregnancy. It often develops in the third trimester of pregnancy. Vitamin C helps maintain hormonal balance in the female body and increases fertility, especially in women with low progesterone levels. It restores the balance between estrogen and progesterone. It promotes better iron absorption. Folic acid belongs to the folate family and affects a number of metabolic processes in the body. It participates in normal homocysteine metabolism and amino acid synthesis. It participates in cell division (including oocyte division) and promotes normal hemopoiesis. Warning: Accidental overdose of iron-containing products is the leading cause of fatal poisoning in children under 6 years of age. Keep this and other iron-containing products out of reach of children. In case of accidental overdose, contact your doctor or poison control center immediately. Indication: Take as directed by your doctor. Take with food. Can be used by vegetarians. Does not contain artificial colors, flavors, or sweeteners; preservatives, sugars, starch, milk, lactose, gluten, yeast, and sodium. Gravida Iron is manufactured to the highest quality standards, including purity and efficacy of ingredients. The preparation is available without a prescription. For best results, take the preparation as directed by your doctor. The pharmacological properties of the preparation are due to the action of its components. Iron is part of hemoglobin, myoglobin, and various enzymes. It participates in oxygen transport and redox reactions in the body. Iron ion penetration into enterocytes occurs via mobilferrin, then it binds to transferrin and circulates in the blood. Iron is deposited in the liver, bone marrow, and spleen in the form of ferritin and hemosiderin. Ferrous fumarate is characterized by erythropoietic, hemopoietic, and anti-anemic action. It rapidly replenishes iron deficiency in the body, resulting in gradual regression of clinical and laboratory symptoms of anemia. Folic acid is necessary for the maturation of megaloblasts and the formation of normoblasts. It stimulates erythropoiesis, participates in the synthesis of amino acids, nucleic acids, purines, and pyrimidines. Folic acid is essential for normal pregnancy, promotes the development of the embryonic neural tube and prevents congenital defects, and protects the fetus from teratogenic factors. Vitamin C (ascorbic acid) promotes iron absorption in the gastrointestinal tract, maintains the colloidal state of intercellular substances, and ensures normal capillary permeability by inhibiting hyaluronidase. Ferrous fumarate is easily absorbed from the duodenum and proximal jejunum because divalent iron is well absorbed, and fumaric acid enhances its absorption. Bioavailability is approximately 35%. Absorption increases in case of iron deficiency in the body, and decreases in case of excess. Cmax is observed after 4 hours. T1/2 is approximately 12 hours. It is excreted mainly with sweat, urine, and feces. Folic acid binds to Castle's intrinsic factor in the stomach and is almost completely absorbed from the proximal duodenum. It binds to plasma proteins by 64%. Cmax is reached in 30-60 minutes. It undergoes biotransformation in the liver. It is eliminated mainly by the kidneys, both unchanged and as metabolites. Simultaneous use of ferrous fumarate and tetracycline antibiotics reduces the absorption of both iron and antibiotics. Antacids containing aluminum, magnesium, and calcium salts reduce iron absorption from the intestine. Ascorbic acid promotes iron absorption. The effect of folic acid is reduced when taken with analgesics, anticonvulsants, antacids, cholestyramine, sulfonamides, antibiotics, contraceptives, and cytostatics. Indications: • Iron deficiency anemia of various etiologies; • Prevention of iron and B vitamin deficiency during pregnancy and lactation: The use of the preparation during pregnancy and breastfeeding is possible only on the recommendation of a doctor. Special use instructions: Taking the preparation may cause dark discoloration of stool and urine. Simultaneous use with other iron-containing preparations is not recommended. Taking the preparation may affect laboratory test results. Effect of the preparation on the ability to drive vehicles and operate machinery: Taking the preparation does not affect the ability to drive vehicles and operate machinery. Side effects: The preparation is well tolerated. Side effects are usually transient. Gastrointestinal system: nausea, vomiting, heartburn, pain and discomfort in the epigastric region, diarrhea or constipation, occult blood in stool; Central nervous system: headache, dizziness, rarely – weakness, irritability; Allergic reactions: skin hyperemia, rarely – rash, itching, in isolated cases – anaphylactic shock. Other: metallic taste in the mouth, toothache, tooth enamel discoloration, sore throat (especially when swallowing), chest pain. Overdose: Overdose symptoms include pain in the epigastric region, nausea, vomiting, diarrhea, melena. These symptoms may be accompanied by acrocyanosis, weakness, lethargy, drowsiness, cold sweat, rapid and shallow breathing, tachycardia. In severe cases, shock, coma may develop. High doses of iron in children under 6 years of age are characterized by high lethality. Treatment is symptomatic: induce vomiting, gastric lavage with a large amount of fluid; intake of milk or raw eggs; in case of severe poisoning – intravenous administration of desferrioxamine; control of vital bodily functions, oxygen therapy, correction of acidosis, rehydration therapy.