Fotili Eye Drops 20mg+6.84mg 5ml Vial #1

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International Name - timolol maleate, pilocarpine Clinical-pharmacological group: Ophthalmology → Antiglaucoma agents → For topical use in ophthalmology → Beta-adrenoblockers Dosage form: Eye drops Content: 1 ml of the preparation contains: Active substances: Pilocarpine hydrochloride 20 mg; Timolol maleate 6.84 mg (equivalent to 5 mg timolol) Excipients: Benzalkonium chloride, citric acid; Sodium citrate; Hypromellose; Water for injection. Description: Clear, colorless solution. Release form: Fotil®, eye drops 20 mg + 5 mg / ml In a 5 ml polyethylene dropper bottle with a plastic tip and screw cap. The dropper bottle is placed in a cardboard box with the instructions for use. Indications: Glaucoma or elevated intraocular pressure when a combination of timolol and pilocarpine is required. - Open-angle and angle-closure glaucoma; - Secondary glaucoma; - Elevated intraocular pressure after ophthalmic surgery. Dosage and administration Usual dosage - 1 drop in the affected eye 2 times a day. In some patients, a sustained reduction in intraocular pressure induced by Fotil® is achieved only after several weeks, so the effectiveness of the therapy should be assessed 4 weeks after the start of treatment. If the patient's intraocular pressure remains elevated during treatment with Fotil® eye drops, it is recommended to continue treatment with Fotil® Forte eye drops - 1 drop 2 times a day. Side effects Ocular: - Blurred vision; - Eye irritation; - Short-term burning and stinging sensation in the eye; - Increased tearing; - Dry eye syndrome; - Eyelid dermatitis; - Conjunctival hyperemia; - Ciliary muscle spasm and induced myopia; - Reduced visual acuity in insufficient light (due to miosis); - Reduced corneal sensitivity; - Punctate keratitis; - Allergic blepharoconjunctivitis. Several cases of retinal detachment, rigidity of the iris or cyst formation in the iris have been reported in association with the use of miotic agents. Reversible opacification of the lens has been observed with prolonged use of pilocarpine. Systemic: Nausea, diarrhea, sweating, excessive salivation and decreased blood pressure, heart failure, exacerbation of bronchial asthma, bradycardia, arrhythmia, temporal and supraorbital headaches, skin rash, urticaria. Timolol crosses the blood-brain barrier and affects the central nervous system. In all patients with heart failure, it can cause asthenic syndrome, nausea, dizziness, anxiety, hallucinations, headache, and depression. Very rarely - nasal congestion, diplopia, and ptosis. Overdose The most common symptoms of overdose with parasympathomimetic drugs and beta-blockers are: bradycardia, decreased blood pressure, bronchospasm, and acute heart failure. Treatment is mainly symptomatic. Atropine can be used as an antidote for pilocarpine. Isoprenaline can be administered intravenously to prevent pronounced bradycardia or bronchospasm, dobutamine to treat arterial hypotension.

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International Name - timolol maleate, pilocarpine Clinical-pharmacological group: Ophthalmology → Antiglaucoma agents → For topical use in ophthalmology → Beta-adrenoblockers Dosage form: Eye drops Content: 1 ml of the preparation contains: Active substances: Pilocarpine hydrochloride 20 mg; Timolol maleate 6.84 mg (equivalent to 5 mg timolol) Excipients: Benzalkonium chloride, citric acid; Sodium citrate; Hypromellose; Water for injection. Description: Clear, colorless solution. Release form: Fotil®, eye drops 20 mg + 5 mg / ml In a 5 ml polyethylene dropper bottle with a plastic tip and screw cap. The dropper bottle is placed in a cardboard box with the instructions for use. Indications: Glaucoma or elevated intraocular pressure when a combination of timolol and pilocarpine is required. - Open-angle and angle-closure glaucoma; - Secondary glaucoma; - Elevated intraocular pressure after ophthalmic surgery. Dosage and administration Usual dosage - 1 drop in the affected eye 2 times a day. In some patients, a sustained reduction in intraocular pressure induced by Fotil® is achieved only after several weeks, so the effectiveness of the therapy should be assessed 4 weeks after the start of treatment. If the patient's intraocular pressure remains elevated during treatment with Fotil® eye drops, it is recommended to continue treatment with Fotil® Forte eye drops - 1 drop 2 times a day. Side effects Ocular: - Blurred vision; - Eye irritation; - Short-term burning and stinging sensation in the eye; - Increased tearing; - Dry eye syndrome; - Eyelid dermatitis; - Conjunctival hyperemia; - Ciliary muscle spasm and induced myopia; - Reduced visual acuity in insufficient light (due to miosis); - Reduced corneal sensitivity; - Punctate keratitis; - Allergic blepharoconjunctivitis. Several cases of retinal detachment, rigidity of the iris or cyst formation in the iris have been reported in association with the use of miotic agents. Reversible opacification of the lens has been observed with prolonged use of pilocarpine. Systemic: Nausea, diarrhea, sweating, excessive salivation and decreased blood pressure, heart failure, exacerbation of bronchial asthma, bradycardia, arrhythmia, temporal and supraorbital headaches, skin rash, urticaria. Timolol crosses the blood-brain barrier and affects the central nervous system. In all patients with heart failure, it can cause asthenic syndrome, nausea, dizziness, anxiety, hallucinations, headache, and depression. Very rarely - nasal congestion, diplopia, and ptosis. Overdose The most common symptoms of overdose with parasympathomimetic drugs and beta-blockers are: bradycardia, decreased blood pressure, bronchospasm, and acute heart failure. Treatment is mainly symptomatic. Atropine can be used as an antidote for pilocarpine. Isoprenaline can be administered intravenously to prevent pronounced bradycardia or bronchospasm, dobutamine to treat arterial hypotension.