Properties
What is it?
International Nonproprietary Name - hyaluronic acid sodium Clinical-pharmacological group: Metabolic disorders → Agents affecting tissue metabolism → Preparations activating tissue metabolism, improving trophic and stimulating regeneration processes → Natural origin preparations Composition 1 ml Sodium hyaluronate . . . . . . . 10 mg Pharmacological properties Sodium hyaluronate is a natural polymer from the glycosaminoglycan class, which is the main and leading component of the physiological function of synovial fluid. Sodium hyaluronate is characterized by viscoelasticity, hygroscopicity, and lubricating properties. Intra-articular injection of Hiruan improves joint function and mobility; normalizes the synovial fluid in the affected joint. Indications Deforming osteoarthritis of the knee joint, shoulder periarthritis. Method of administration and dosage Hiruan injection is administered directly into the knee or shoulder joint once a week for 5 weeks. The number of injections is determined by the symptoms and severity of the disease. Hiruan injection is administered directly into the joint space (synovial fluid), and therefore, the sterility of the procedure must be strictly observed. Side effects Hypersensitivity: swelling (face, eyelids), facial redness, rarely rash, urticaria, itching. In such cases, it is recommended to discontinue treatment with Hiruan and conduct adequate treatment. At the injection site: pain (transient), swelling, redness, sensation of heat and heaviness may develop. Nausea, vomiting, and fever may develop. Serious side effects: In case of development of shock symptoms, treatment is immediately discontinued and adequate treatment is carried out. Contraindications Increased sensitivity to sodium hyaluronate. Precautions Before starting treatment with Hiruan, it is necessary to eliminate the inflammatory process in the joint, as Hiruan may exacerbate the symptoms of inflammation. In case of fluid retention in the joint, arthrocentesis is recommended. Treatment with Hiruan is discontinued in case of ineffective treatment after the first 5 weeks. Intravenous injection of Hiruan is not allowed. Hiruan is very viscous, so it is preferable to use a 22-23 G needle for injection. Hiruan is stored at 2-8°C, 30 minutes before injection, the preparation should be kept at room temperature; Intra-articular injection of Hiruan is performed immediately after opening the preparation. Special instructions Hiruan is prescribed with caution in case of hypersensitivity to other medications, liver diseases or impaired liver function tests. It is prescribed with caution in children, the elderly, and pregnant women, as there are no studies on the safety of sodium hyaluronate use. During breastfeeding, it is recommended to stop lactation. Interaction with other drugs Precipitation of Hiruan can be caused by disinfectants, ammonium salts - benzalkonium chloride, chlorhexidine. Storage conditions and shelf life Store in a dark, hermetically sealed container at a temperature of 2-8°C in the refrigerator. Shelf life: 3 years (36 months)