Properties
What is it?
International Nonproprietary Name - cyanocobalamin Clinical-pharmacological group: Vitamins, multivitamins, trace elements → Vitamin preparations → Water-soluble vitamins → B group vitamins Clinical-pharmacological group: Vitamin preparations. Vitamin B12 (cyanocobalamin and its derivatives) Active substance: Each 1 ml ampoule contains Vitamin B12 (cyanocobalamin) 1000 mcg. Excipients: Sodium chloride 9 mg, Benzyl alcohol 15 mg, Water for injection. Indications: - Acute neuritis, neuralgia - Trigeminal neuralgia - Sciatica - Intercostal neuralgia - Pernicious anemia (impaired absorption of vitamin B12) - Hyperchromic macrocytic anemia caused by vitamin B12 deficiency Dosage regimen: For intramuscular injection only. In acute neuralgia, administer 500-1000 mcg of Vitamin B12 intramuscularly. Maintenance therapy for acute neuritis and neuralgia is recommended for 10 days. In case of relapse, Cobalexin should be repeated. For pernicious anemia and hyperchromic macrocytic anemia, treatment begins with 250-1000 mcg every other day for 1-2 weeks. Then, 250 mcg is administered once a week until blood test results return to normal. When neuropathic complications are pronounced, 1000 mcg is administered every other day. When blood test results return to normal, maintenance therapy continues with 1000 mcg intramuscularly once a month. Contraindications: • Hypersensitivity to cyanocobalamin • Leber's disease (hereditary optic neuropathy) Pregnancy and lactation: Pregnancy: Pregnancy Category C. It is not permissible to use it during pregnancy for the treatment of megaloblastic anemia without confirmed vitamin B12 deficiency. Lactation: Excreted in breast milk. If necessary, use as directed by a physician. Overdose: Excess doses of water-soluble vitamins are excreted in the urine; no antidote is required. Interactions with other drugs: It is not recommended to take with alcohol due to reduced absorption of vitamin B12. The therapeutic effect of vitamin B12 may be reduced when chloramphenicol is used. The drugs methotrexate, pyrimethamine, colchicine, and para-aminosalicylic acid may cause incorrect results in blood tests for vitamin B12 concentration.