Properties
- Form
- tableti
- Dosage mg
- 500
- Pack
- 10
What is it?
International Nonproprietary Name - levofloxacin Composition: 250 mg tablets: Each tablet contains 250 mg of levofloxacin as the active substance, equivalent to 256.23 mg of levofloxacin hemihydrate. 500 mg tablets: Each tablet contains 500 mg of levofloxacin as the active substance, equivalent to 512.46 mg of levofloxacin hemihydrate. Indications: For the treatment of moderate to severe infections in adults caused by microorganisms susceptible to levofloxacin: Acute sinusitis; Exacerbation of chronic bronchitis; Community-acquired pneumonia; Uncomplicated urinary tract infections; Complicated urinary tract infections, including pyelonephritis; Skin and soft tissue infections. Levofloxacin tablets are taken 1-2 times daily. The dose depends on the type and severity of the infection, as well as the susceptibility of the causative pathogen. Duration of treatment: The duration of treatment depends on the course of the disease. The maximum duration is 14 days. Like other antibiotics, treatment with levofloxacin tablets should be continued for at least 48-72 hours after the patient becomes afebrile or bacterial eradication occurs. Indication | Dosage regimen (according to severity) | Duration of treatment Acute sinusitis | 500 mg once daily | 10-14 days Exacerbation of chronic bronchitis | 250-500 mg once daily | 7-10 days Community-acquired pneumonia | 500 mg 1-2 times daily | 7-14 days Uncomplicated urinary tract infection | 250 mg once daily | 3 days Complicated urinary tract infection, including pyelonephritis | 250 mg once daily | 7-10 days Skin and soft tissue infection | 250 mg once daily or 500 mg 1-2 times daily | 7-14 days Side effects: Allergic reactions Infrequent | Pruritus, rash. Rare | Urticaria, bronchospasm/dyspnea. Very rare | Angioedema, hypotension, anaphylactoid shock, photosensitivity, severe bullous skin eruptions such as Stevens-Johnson syndrome, toxic epidermal necrolysis (Lyell's syndrome), and exudative erythema multiforme. Skin and mucous membrane reactions, as well as anaphylactoid reactions, may occur after the first dose. Neurological complaints Infrequent | Headache, dizziness, somnolence, insomnia. Rare | Pruritus, tremor, anxiety, depression, psychotic reactions, agitation, confusion, convulsions. Very rare | Hypoesthesia, visual and auditory disturbances, taste and smell disturbances, hallucinations. Contraindications: Levofloxacin tablets are contraindicated in patients with a history of epilepsy. Like other quinolones, it should be used with particular caution in patients prone to convulsions, for example, in patients with a history of central nervous system disorders, who are being treated concomitantly with fenbufen or other similar non-steroidal anti-inflammatory drugs that lower the seizure threshold, such as theophylline.
