Mesatone Injectable Solution 1% 1ml Ampule #10

International Nonproprietary Name - Phenylephrine Hydrochloride Pharmacological Group: Local vasoconstrictor preparations International and Chemical Names: Phenylephrine; 1-(meta-hydroxyphenyl)-2-methylaminoethanol hydrochloride; Composition: Phenylephrine hydrochloride – 0.01 g; Excipients: Heparin, water for injection. Dosage Form. Solution for injection. Pharmacotherapeutic Group. Adrenergic and dopaminergic preparations. Indications for Use. Mesaton is prescribed to increase blood pressure in cases of collapse and hypotension resulting from reduced vascular tone, during preparation for and during surgery, in hypotonic disease, for narrowing of the nasal mucosa blood vessels and to alleviate vasomotor rhinitis, as a substitute for adrenaline in local anesthetic solutions, during intoxication, infectious diseases, and for pupil dilation. Method of Administration and Dosage. Mesaton is administered intravenously, subcutaneously, intramuscularly, and as eye drops/solution. In cases of acute drop in blood pressure, the drug is usually administered intravenously in doses of 0.1-0.3-0.5 ml of 1% solution in 20 ml of 5-20% glucose solution or in the same volume of isotonic sodium chloride solution. Administration is carried out slowly, and if necessary, it is repeated. For intravenous infusion, 1 ml of Mesaton 1% solution is administered in 250-500 ml of 5% glucose solution. For subcutaneous and intramuscular administration in adults, doses of 0.3-1 ml of 1% solution are used. For pupil dilation, 2-3 drops of a 1-2% solution of the preparation are instilled into the conjunctival sac. To narrow the blood vessels of the nasal mucosa and reduce inflammation, a 0.25-0.5% solution is instilled or applied to the mucous membranes. 0.3-0.5 ml of Mesaton solution is added to local anesthetics (per 10 ml of anesthetic solution). Maximum Doses for Adults: Intravenous – single dose 0.005 g, daily dose 0.025 g. Subcutaneous and intramuscular – single dose – 0.01 g, daily dose – 0.05 g. Side Effects. May occur, especially with overdose, including hypertension, palpitations, ventricular fibrillation, dyspeptic symptoms, cerebral hemorrhage, dizziness, feeling of fear, anxiety, weakness, headache, paleness of facial skin, tremor, convulsions. With local ophthalmological use – eye pain, headache, conjunctival hyperemia, allergic reaction of the eyelids. Contraindications. Arterial hypertension, atherosclerosis, tendency to vascular spasms, unstable angina, diabetes mellitus, pregnancy.