Properties
What is it?
International Nonproprietary Name - phenylephrine Trade Name: Midoptik International Nonproprietary Name: Phenylephrine Description: Clear, colorless or slightly yellowish liquid. Composition: Active substance: Phenylephrine hydrochloride – 0.25 g; Excipients: Boric acid - 0.05 g, Sodium metabisulfite - 0.004 g, Disodium edetate – 0.0005 g, Preservative – Benzalkonium chloride - 0.001 g, Water for injections – up to 10 ml. Pharmacotherapeutic group Alpha-adrenomimetic, vasoconstrictor agent. Indications Pupil dilation in intraocular surgery; in diagnostic studies: for ophthalmoscopy, retinoscopy, refraction; treatment of uveitis complicated by synechiae; prevention of synechiae. Routes of administration and dosage To achieve mydriasis and vasoconstriction – one drop, repeated as needed after 1 hour. In the treatment of uveitis complicated by synechiae and for the prevention of synechiae – one drop, but no more than 3 times a day. If necessary, treatment is repeated the next day. Before surgical intervention - one drop 30-60 minutes before surgery; During ophthalmoscopy - one drop 15-30 minutes before examination. Side effects Local reactions: allergic reactions (burning, discomfort in the eyes, conjunctival hyperemia), pain in the superciliary region, lacrimation, photosensitivity. Systemic reactions: dizziness, headache, tachycardia, increased blood pressure, increased sweating, paleness, anxiety. Contraindications Hypersensitivity to phenylephrine and sulfites, ventricular fibrillation, tendency to angiospasm, serious cerebrovascular disorders, decompensated heart failure, severe forms of GID, pheochromocytoma, hyperthyroidism, pronounced atherosclerosis, angle-closure glaucoma, neonatal period (for low birth weight infants). With caution Angina pectoris of functional class III-IV, diabetes mellitus, arterial hypertension, idiopathic orthostatic arterial hypotension, pregnancy, lactation, elderly age, children under 12 years of age. Overdose Systemic side effects are usually not observed with local use, but with overdose, especially with prolonged use, cardiac rhythm disturbances, increased blood pressure, insomnia, excitement, paleness may occur. Specific treatment: For hypertensive effect, an alpha-adrenoblocker such as phentolamine 5-10 mg IV may be prescribed, repeated as needed. Storage conditions and shelf life Store at a temperature of 8-25˚ C, out of reach of children. Shelf life - 2 years. The preparation should not be used after the expiry date indicated on the packaging. After opening the vial, the preparation should be used within 1 month.