Properties
What is it?
International Nonproprietary Name - NIMODIPINE Clinical-pharmacological group: Calcium slow channel blocker. Composition and dosage form: 1 tab. Nimodipine .............. 30 mg Indications: Nimodipine intravenous infusion: For the prevention and treatment of ischemic neurological disorders caused by vasospasm after aneurysmal subarachnoid hemorrhage; For the prevention of ischemic neurological disorders after traumatic subarachnoid hemorrhage; In elderly patients with pronounced disorders of brain function (decreased memory, concentration, driving ability, emotional lability) Before treatment, it should be determined that the symptoms are not caused by diseases that require specific treatment. Method of administration and dosage: For aneurysmal subarachnoid hemorrhage: It is recommended to use nimodipine intravenously by infusion for 5-14 days, at a dose of 1 mg. The duration of the first infusion is 2 hours. With good tolerance to the drug, 2 mg is administered by infusion over the next 2 hours, and after infusion treatment, 2 tablets 6 times a day. For traumatic subarachnoid hemorrhage: It is recommended to use Nimotop intravenously for 7-10 days, followed by tablets: 2 tablets 6 times a day. For disorders of brain function in the elderly: It is recommended to take 1 tablet 3 times a day (3 times 30 mg). In case of adverse reactions, the dose should be reduced or discontinued. In case of severe liver disease, the dose should be reduced or discontinued. In case of impaired liver function, especially cirrhosis, the bioavailability of nimodipine may increase due to reduced first-pass metabolism and metabolic inactivation. Consequently, the therapeutic and side effects of the drug increase, especially the hypotensive effect. In this case, the dose of the drug should be reduced according to blood pressure readings. Aneurysmal subarachnoid hemorrhage: After infusion for 5-14 days, take tablets for 7 days. Traumatic subarachnoid hemorrhage: 7-10 days of infusion followed by tablets for 11-14 days. Disorders of brain function in the elderly: If treatment lasts for several months, the indications should be justified for continuing treatment. The tablet is taken with a small amount of water, independently of meals, no more often than once every 4 hours. Side effects: Gastrointestinal tract: nausea, gastrointestinal discomfort, intestinal obstruction (due to paresis). CNS: dizziness, headache, weakness, insomnia, motor agitation, aggression, sweating. Cardiovascular system: decreased blood pressure, facial hyperemia, feeling of warmth, bradycardia, rarely tachycardia. Blood changes: rarely thrombocytopenia. Skin: skin redness, peripheral edema.