Properties
- Form
- tableti
- Dosage mg
- 500
- Pack
- 10
What is it?
Composition One tablet (film-coated) of the preparation contains 500 mg of the active substance – ornidazole. Pharmacological Properties Antiprotozoal preparation with antimicrobial activity. The mechanism of action is related to the disruption of the DNA structure of microorganisms sensitive to ornidazole. After penetrating the microbial cell, ornidazole binds to its DNA, inhibits the synthesis of nucleic acids, which ultimately leads to bacterial death. Sensitive to ornidazole: Trichomonas vaginalis, Gardnerella vaginalis, Giardia intestinalis, Entamoeba histolytica; anaerobic microorganisms: Bacteroides spp. (including Bacteroides fragilis, Bacteroides distasonis, Bacteroides ovatus, Bacteroides thetaiotaomicron, Bacteroides vulgatus), Fusobacterium spp., Veillonela spp., Prevotella spp. (Prevotella bivia, Prevotella buccae, Prevotella disiens); gram-positive microorganisms: Eubacterium spp., Clostridium spp. Aerobic microorganisms are resistant to the preparation. Ornidazole is well absorbed from the digestive system. Maximum concentration is reached 1-3 hours after administration. It binds to plasma proteins by 15%. It crosses the blood-brain barrier. It is metabolized in the liver and excreted in the form of metabolites in urine (60-70%) and feces (20-25%), while approximately 5% of the administered preparation is excreted unchanged. T1/2 - 13 hours. Indications - Trichomoniasis; - Amebiasis, amebic dysentery, extraintestinal amebiasis (including amebic liver abscess); - Giardiasis; - Prevention of infections caused by anaerobic bacteria after gynecological and colorectal surgery. Dosage and Administration The preparation is taken orally after meals. For trichomoniasis in adults, 500 mg (1 tablet) is prescribed 2 times a day for 5 days. To prevent reinfection, the patient's sexual partner undergoes the same course of treatment. In children, the daily dose is 25 mg/kg of body weight and is prescribed in a single dose. Contraindications - Hypersensitivity to the components of the preparation; - Organic diseases of the central nervous system; - First trimester of pregnancy and lactation period. Pregnancy and Lactation The preparation is contraindicated in the first trimester of pregnancy and during lactation.
