Properties
What is it?
International Nonproprietary Name - DOXOFYLLINE Active Substance: DOXOFYLLINE Clinical-Pharmacological Group: Bronchial asthma treatment; Bronchodilator; Phosphodiesterase inhibitor. Composition and Dosage Form: Tablets: 10 and 20 tablets per blister. 1 tablet Doxofylline ............ 400 mg Excipients: Colloidal silicon dioxide, wheat starch, mannitol, povidone, microcrystalline cellulose, talc, magnesium stearate. Syrup 2%: In a bottle. 100 ml Doxofylline ......... 2 g Excipients: Sucrose, sodium saccharin, ammonium glycyrrhizinate, sodium methylparaben, sodium propylparaben, alpine flavor, mint flavoring powder, purified water. Indications: PUROXAN is prescribed for patients with bronchial asthma and chronic obstructive pulmonary diseases. Dosage and Administration: Tablets Adults: Use 1 tablet (400 mg) 2 times a day. The dose may be increased up to 1200 mg according to doctor's prescription. In elderly patients with cardiovascular, liver, and gastrointestinal diseases, the dose may be reduced to 1/2 tablet 2 times a day. Syrup Children: The recommended daily dose of doxofylline is 12 mg/kg per day in two divided doses. In case of insufficient effect, under medical supervision, the dose can be increased up to 18 mg/kg. Adults: Use 2 measuring cups - 20 ml (400 mg) 2 times a day. Elderly: Use 1 measuring cup = 10 ml (200 ml) 2 times a day. Side Effects: ♦ Rarely observed: nausea, vomiting, headache, irritability, insomnia, palpitations, and tachycardia. Contraindications: * Contraindicated in patients with hypersensitivity to the components of the preparation. Pregnancy and Lactation: * Animal studies have shown that doxofylline does not harm the fetus and reproductive capacity. Nevertheless, its administration during pregnancy is only in cases of extreme necessity. There are no reports of doxofylline use in breastfeeding mothers. Special Instructions: ◄ The half-life of doxofylline may increase in severe liver and heart failure. ◄ Some drugs inhibit the excretion of xanthines (including doxofylline) from the body, for example: erythromycin, troleandomycin, lincomycin (and other antibiotics of this group), allopurinol, cimetidine, propranolol, anti-influenza vaccine. In this case, the dose of doxofylline needs to be reduced. ◄ Phenytoin, along with other anti-convulsants, and smoking accelerate the excretion and half-life of doxofylline: the dose may need to be increased. ◄ Doxofylline is prescribed with caution in patients with gastric or duodenal ulcer disease, or in the elderly with impaired liver function. Overdose: Although serious cardiac rhythm disturbances are not proven with doxofylline overdose, their complete exclusion is impossible, as it is a xanthine derivative. With significant overdose, seizures may occur, which are its primary symptom. In case of side effects, it is necessary to discontinue treatment. Resumption of treatment with reduced doses is allowed only by doctor's prescription. Drug Interactions: Doxofylline should not be administered with other xanthine derivatives. Cases of toxic synergism of xanthines and ephedrine have been described. Some drugs inhibit the excretion of xanthines (including doxofylline) from the body, for example: erythromycin, troleandomycin, lincomycin (and other antibiotics of this group), allopurinol, cimetidine, ranitidine, propranolol, anti-influenza vaccine. No dependence between doxofylline serum levels and any adverse effects has been identified.