Properties
What is it?
International Nonproprietary Name - Phenylephrine Hydrochloride Benzocaine. Trade Name - RELIEF ADVANCE. Dosage Form - Rectal suppositories. Description - Opaque, white to pale yellow, torpedo-shaped suppositories. Composition - Active substance (1 suppository contains): Benzocaine 206mg. Excipients: Cocoa butter, corn starch, methylparahydroxybenzoate (E218), propylparahydroxybenzoate (E216). Indications - Symptomatic agent for complex treatment of hemorrhoids and anal fissures. Method of administration and dosage - The preparation is used after hygienic procedures. One suppository is inserted into the rectum up to 4 times a day (in the morning, before bedtime, and after each bowel movement). Duration of treatment is determined by the doctor, taking into account the characteristics of the disease, tolerance to the preparation, and achieved effects. Side effects - The following side reactions may develop: contact dermatitis, allergic skin reactions (hyperemia, rash, itching), local reactions in the area of preparation application. Application of the preparation may cause methemoglobinemia (with cyanosis of the skin, lips and finger phalanges, headache, dizziness, respiratory distress, general weakness, tachycardia). In case of development of side reactions not described herein, it is necessary to discontinue the use of the preparation and consult a doctor. Contraindications - Individual hypersensitivity to the preparation's ingredients, as well as to other amide-type anesthetic agents, thromboembolism (including history of), granulocytopenia. Overdose - In cases of significant overdose of recommended single and daily doses, a tendency to hypercoagulation is observed. With benzocaine overdose and systemic absorption, the following disorders may manifest: drowsiness, restlessness, agitation, in severe cases - convulsions. Treatment is symptomatic. Cases of methemoglobinemia (with cyanosis of the skin, lips and finger phalanges, headache, dizziness, respiratory distress, general weakness, tachycardia) have been reported with benzocaine-containing preparations, which can lead to a fatal outcome, and therefore requires urgent medical assistance. Seek the hospital emergency department immediately upon detection of the above-mentioned symptoms. Use in children - The use of the medicinal product is not recommended in children under 12 years of age.