Properties
What is it?
International Nonproprietary Name - Drotaverinum Pharmacological group: Drugs affecting smooth muscle tone and motility International Nonproprietary Name: Drotaverini hydrochloridum Chemical name - 1-(3,4-diethoxybenzylidene)-6,7-diethoxy-1,2,3,4-tetrahydroisoquinoline hydrochloride Composition of the medicinal form: Drotaverini hydrochloridum 40mg, suppository base: semi-synthetic glycerides Dosage form: Rectal suppositories, cylindrical-conical shape, white-yellowish color. On longitudinal section - homogeneous mass, without inclusions. The presence of air, porous voids and funnel-shaped indentations is allowed on the cut. Pharmacotherapeutic group: Spasmolytic, vasodilator Pharmacotherapeutic properties: Pharmacodynamics Relaxes the smooth muscles of internal organs and blood vessels. The mechanism of action consists in the inhibition of phosphodiesterase IV, which leads to the accumulation of cAMP and phosphorylation of the short chains of myosin kinase. Rapidly and completely absorbed from the gastrointestinal tract. Evenly distributed in tissues. Effectively relaxes the smooth muscles of internal organs and blood vessels, lowers blood pressure. Does not affect the autonomic nervous system and CNS. Pharmacokinetics: Rapidly absorbed from the gastrointestinal tract. Distributed evenly. Excreted by the kidneys. Indications: Spasm of the smooth muscles of internal organs. Cardiospasm and pylorospasm, chronic gastroduodenitis, gastric and duodenal ulcer disease, chronic calculous cholecystitis, chronic pancreatitis, meteorism, tenesmus. Renal colic, pyelitis, cystitis. Spasm of cerebral, coronary and peripheral arteries. Algomenorrhea, threatened abortion and threatened premature labor. Method of administration and dosage: Rectally, one suppository 3-4 times a day. In children, one suppository 1-2 times a day. Side effects: Dizziness, increased heart rate, feeling of heat, increased sweating, allergic reactions. Contraindications: Established intolerance to the drug, glaucoma.