Properties
What is it?
International Nonproprietary Name - Azithromycinum Pharmacological Group: Macrolide Group Pharmacological Properties Pharmacodynamics. Possesses a broad spectrum of antimicrobial action. Binds to the 50S ribosomal subunit, inhibiting protein biosynthesis in microorganisms. Exhibits bactericidal action at high concentrations. Active against Gram-positive, Gram-negative, anaerobic, intracellular, and other microorganisms. Dosage and Administration Oral, once daily, at least 1 hour before meals or 2 hours after meals. Infections of the upper and lower respiratory tract, skin, and soft tissues (excluding erythema migrans): Total dose 30 mg/kg, 10 mg/kg once daily for 3 days. Erythema migrans: Total dose of the preparation is 60 mg/kg once daily, 20 mg/kg on the first day and 10 mg/kg on subsequent days from day 2 to day 5. Gastric and duodenal diseases associated with Helicobacter pylori: 20 mg/kg once daily, in accordance with doctor's recommendation, along with antisecretory agents and other medicinal products. In case a dose is missed, it should be taken as soon as possible, after which subsequent doses should be taken at 24-hour intervals. Sexually transmitted infections: Uncomplicated urethritis/cervicitis - 1 g once. Complicated, prolonged urethritis, cervicitis caused by Chlamydia trachomatis - three times 1 g at 7-day intervals (1-7-14). Course dose 3 g. Preparation of Suspension. To prepare 20 ml of suspension (nominal volume), add 12 ml of water to a vial containing 400 mg of azithromycin. The shelf life of the prepared suspension is 5 days at room temperature of 15-25°C. To prepare 15 ml of suspension, add 8 ml of water to a vial containing 600 mg of azithromycin. The shelf life of the prepared suspension is 5 days, at a temperature not exceeding 15-25°C. To prepare 30 ml of suspension, add 14.5 ml of water to a vial containing 1200 mg of azithromycin. To prepare 37.5 ml of suspension, add 16.5 ml of water to a vial containing 1500 mg of azithromycin. The shelf life of the prepared suspension is 10 days, at a temperature not exceeding 25°C. Measure the required volume of water using a dosing syringe and add it to the vial containing the powder. Before use, shake the contents of the vial until a homogeneous suspension is obtained. Use a syringe or measuring spoon for dosing the prepared suspension. After using the suspension, to rinse and ingest any remaining suspension in the oral cavity, the child should drink a few sips of tea or juice. After use, the syringe should be disassembled, washed with running water, and dried. The syringe should be stored with the preparation. Indications for Use - Infections of the ear, nose, and throat (bacterial pharyngitis/tonsillitis, sinusitis, otitis media); - Lower respiratory tract infections (bacterial bronchitis, interstitial and alveolar pneumonia, exacerbation of chronic bronchitis); - Skin and soft tissue infections (erythema migrans - early stage of Lyme disease, impetigo, secondary pyodermas); - Sexually transmitted infections (urethritis, cervicitis); - Gastric and duodenal diseases associated with Helicobacter pylori; Side Effects Mostly mild to moderately severe side effects are observed, which are reversible upon completion of the treatment course or discontinuation of the preparation. Gastrointestinal tract: nausea, vomiting, flatulence, constipation, abdominal pain, rarely cholestatic jaundice, anorexia, gastritis, very rarely - candidiasis of the oral mucosa. Allergic reactions: rash, itching, urticaria; rarely - angioneurotic edema and anaphylactic shock.