Properties
What is it?
International Nonproprietary Name - Alumen, Magnesium hydroxide, Oxetacaine Composition One sachet (10 ml) contains: Oxetacaine -------- 20 mg Aluminum hydroxide dry gel and Magnesium hydroxide -- 778 mg (Aluminum hydroxide dry gel 582 mg/Magnesium hydroxide 196 mg) Indications Severe-chronic pain, gastritis, duodenal ulcer, esophagitis, abdominal pain with dyspepsia, during radiotherapy. Dosage and Administration Adults: 1/2 – 1 sachet, 4 times a day. Precautions Contraindications: The preparation (Trigel) is not recommended for use in patients with hypersensitivity to the preparation; the preparation should be used with caution in patients taking other medications concurrently; Side effects 1) Digestive system: diarrhea, constipation, flatulence; 2) Phosphate deficiency; 3) Hypermagnesemia and renal failure when taken in large doses; 4) Dry mouth or altered taste, rarely skin rash, paralysis in case of hypersensitivity. If these symptoms persist and worsen, appropriate treatment is necessary, for example, reduce the dose of the preparation or discontinue its use and consult a doctor or pharmacist for advice. 5) Rarely, headache, drowsiness, dizziness, and fatigue; Use during pregnancy and lactation 1) The preparation cannot be used in the first trimester of pregnancy; 2) It is not established whether the preparation is excreted in breast milk. Precautions for use 1) Patients with a history of hypermagnesemia or magnesium deficiency; 2) The preparation cannot be used in patients with intestinal stenosis and acute appendicitis. 3) The preparation is not recommended for use in children. 4) The use of magnesium-containing antacids in patients with mild to moderate renal insufficiency should be done with caution due to the increased risk of hypermagnesemia; 5) Precautions are necessary due to aluminum accumulation in the nervous system and skeletal system. 6) Follow the dosage and usage instructions; 7) When taking the preparation, it should be swallowed quickly to avoid oral paralysis. 8) Pain relief occurs after the suspension spreads over the surface of the damaged mucous membrane, so no liquid should be taken for a short time after taking the preparation. 6. Drug interactions 1) The absorption rate and/or level of many drugs in the kidney may increase or decrease when used with aluminum-containing antacids. 2) Therefore, generally, the preparation should not be taken one or two hours after taking antacids, if possible; 3) Drug interactions in clinical studies: 1) Drugs that increase reabsorption in the kidney: acetylsalicylic acid, naproxen, metoprolol, levodopa. 2) Drugs that decrease reabsorption in the kidney: tetracycline, ciprofloxacin, ofloxacin, chenodeoxycholic acid, sodium fluoride, enoxacin, norfloxacin, levothyroxine, coumarin derivatives. 3) Drugs that alter reabsorption in the kidney: digoxin, captopril, cimetidine, ranitidine, famotidine, theophylline, propranolol, atenolol, ferrous sulfate, chlorpromazine, isoniazid. 7. Keep out of reach of children, do not store in another container. Storage: In a tightly closed container, at room temperature not exceeding 250C, protected from sunlight. Shelf life: 3 years The preparation is manufactured in accordance with the Korean Good Manufacturing Practice recommended by the World Health Organization.