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International Name - Lidocaine Hydrochloride Lidocaine-Liquor Synonyms: Lignocaine, Lidocaine Hydrochloride, Xylocaine, Lidocar. Dosage Form: Solution for injection 2% and 1% Composition: Active Substance: Lidocaine Hydrochloride 20 mg/ml and 10 mg/ml Excipients: Sodium Chloride. Description: The preparation is a colorless or slightly yellowish transparent liquid. Pharmacotherapeutic Group: Local anesthetic, antiarrhythmic agent of group I-B. Indications: Ventricular extrasystole and tachycardia, especially in the acute period of myocardial infarction, prophylaxis of ventricular fibrillation, glycoside intoxication, cardiac surgery. Terminal, infiltrative, conductive anesthesia; also for local anesthesia in dentistry, ophthalmology, otorhinolaryngology, obstetrics and gynecology, surgery, dermatology, blockade of peripheral nerves and nerve ganglia. In obstetrics: before episiotomy and during suturing. Method of Administration and Dosage: Cardiology Practice: Administration of the preparation is initiated with an intravenous bolus dose of 1 mg/kg. To maintain its therapeutic concentration in the blood, lidocaine infusion is repeated at a dose of 0.5 mg/kg every 8-10 minutes, if necessary, with a total dose of 3 mg/kg. After the first dose, a maintenance infusion is started at 2-4 mg/min (30-50 mcg/kg/min); drip infusion is possible for 24-36 hours. For infusion, 2% Lidocaine-Liquor solution is diluted to a concentration of 2-4 mg/ml in isotonic sodium chloride solution. In patients with heart failure, shock, liver dysfunction, and over 70 years of age, the initial or maintenance dose is reduced by 50%. In such cases, dynamic monitoring of lidocaine concentration in blood plasma is necessary during prolonged infusion. Endotracheal and intramuscular administration is used only when intravenous administration is impossible. Lidocaine is administered intramuscularly at a dose of 2-4 mg/kg (maximum single dose is 200 mg) at 4-6 hour intervals. In case of myocardial infarction, 4 mg/kg (maximum - 200-300 mg) before hospitalization. For the use of the preparation in surgery and obstetrics, dentistry, ENT practice, the dosage regimen is determined individually according to indications, clinical situation and the dosage form used. Lidocaine solution is compatible with epinephrine. If necessary, 1 drop of 0.1% epinephrine hydrochloride solution is added to 10 ml of the preparation (immediately before use) and not more than 5 drops to the entire solution. For local anesthesia, the maximum dose of the preparation is 200 mg, with epinephrine - 500 mg. Side Effects: Headache, dizziness, insomnia, restlessness. In patients with hypersensitivity, seizures, tremor, paresthesia, euphoria, disorientation, tinnitus, slowed speech may occur with rapid intravenous administration of the preparation. With the use of high doses of the preparation, bradycardia, slowed conduction, arterial hypotension may occur. Contraindications: Severe bradycardia, hypovolemia, severe arterial hypotension, sinoatrial, atrioventricular or intraventricular blockades, cardiogenic shock, severe forms of chronic heart failure, hypersensitivity to the preparation and/or other amide group local anesthetics, Adams-Stokes and Wolff-Parkinson-White syndromes;