Properties
What is it?
Suprastin 20mg/1ml 5 ampoules Suprastin tablets see here: Suprastin 25mg tab Composition Suprastin® solution for injection Composition: Each 1 ml ampoule contains 20 mg of Chloropyramine Hydrochloride. In addition to Chloropyramine Hydrochloride, the solution for injection contains water for injection. Solution for intramuscular injection. In acute, severe cases, it can be administered intravenously. See blog: Suprastin tablet and ampoule — necessary information before using the medication Suprastin - an experienced and reliable ally in the fight against allergies Indications - Allergic diseases, for example: seasonal allergic rhinitis, conjunctivitis, urticaria, dermatographism, contact dermatitis, food and drug allergies, insect bite allergy, skin itching. - Adjuvant therapy for systemic anaphylactic reaction and angioneurotic edema. - The sedative side effect of the preparation should be considered when prescribing it. Dosage and administration In adults: The recommended daily dose is 1-2 ampoules intramuscularly. In children: Recommended initial dose: For 1-12 months of age: ¼ ampoule intramuscularly; For 1-6 years of age: ½ -1 ampoule intramuscularly. The dose can be increased with caution, considering the patient's reaction and side effects, however, the dose should not exceed 2 mg/kg of body weight. In case of anaphylactic shock or acute, severe allergic reaction, it is recommended to start treatment with a careful, slow intravenous injection, followed by continuation of injections intramuscularly or oral administration of the preparation. Special patient groups: Elderly and debilitated patients: Suprastin should be used with particular caution, as antihistamines often cause side effects in these patients (dizziness, drowsiness, decreased blood pressure). Liver dysfunction: Dose reduction may be necessary due to decreased metabolism of the active component of the preparation in case of liver diseases. Kidney dysfunction: It may be necessary to change the administration regimen and reduce the dose because the active component is mainly excreted by the kidneys. Side effects The following side effects may occur during the use of Suprastin: Central nervous system: sedative effect, fatigue, dizziness, ataxia, nervous excitation, tremor, convulsions, headache, euphoria, encephalopathy, visual impairment. Cardiovascular system: hypotension, tachycardia, arrhythmia. Gastrointestinal tract: discomfort in the epigastrium, dry mouth, nausea, vomiting, constipation, diarrhea, loss or increase of appetite, pain in the epigastric region. Skin and connective tissue: increased sensitivity to light. Hematopoietic system: rarely leukopenia, agranulocytosis, hemolytic anemia, other blood disorders. Other: dysuria, urinary retention, myopathy, increased intraocular pressure, glaucoma attack, photosensitization. Contraindications Hypersensitivity to the active substance; acute asthma attack; not for use in premature and full-term newborns; in pregnant and lactating women. Pregnancy and lactation a) Preclinical studies No data from preclinical studies are available. b) Studies in humans Adequate, well-controlled studies on the use of the preparation in pregnant women have not been conducted. However, the development of connective tissue behind the lens of the eye in newborns whose mothers received antihistamines during the last two weeks of pregnancy has been described. Therefore, Suprastin can be taken during pregnancy, especially in the first trimester and the last month, only after careful analysis of risks and benefits. Due to the lack of adequate, well-controlled study data on the use of Suprastin during breastfeeding, it should not be prescribed to nursing mothers. Special precautions Suprastin should be used with particular caution. Due to the anticholinergic and sedative effects, caution is required when prescribing Suprastin to elderly patients, as well as in cases of liver dysfunction, cardiovascular pathologies, narrow-angle glaucoma, urinary retention, and prostatic hypertrophy. In combination with ototoxic drugs, Suprastin can mask the early signs of ototoxicity. Prolonged use of antihistamines can rarely cause blood formation disorders (leukopenia, agranulocytosis, thrombocytopenia, hemolytic anemia). In case of prolonged use of the preparation, if fever of unknown origin, laryngitis, ulceration of the oral mucosa, jaundice, pallor, bruising, unusual or difficult-to-stop bleeding develops, blood cell counts should be determined, and if blood formation disorders are detected, the use of the preparation should be discontinued. Use of Suprastin in relation to food and drink. Alcohol can enhance the sedative effect of antihistamines on the central nervous system, therefore, alcohol consumption should be avoided during the course of treatment with Suprastin. Driving and operating machinery The preparation, especially at the beginning of treatment, can cause drowsiness and psychomotor impairment. Therefore, during the initial period, the duration of which is determined individually, driving vehicles and performing work associated with an increased risk of accidents is prohibited. After this, the level of restriction or prohibition of driving and operating machinery should be determined individually by the doctor for each patient. Overdose Intentional or accidental overdose of antihistamines, especially in newborns or children, can lead to patient death. In case of Suprastin overdose, symptoms and signs similar to atropine poisoning develop: hallucinations, ataxia, impaired coordination of movements, athetosis, convulsions. Excitation predominates in young children. Sometimes dry mouth, fixed dilated pupils, facial redness, sinus tachycardia, urinary retention, fever are observed. Fever and facial redness are not always present in adults, and the period of excitation is followed by convulsions and post-convulsive depression. Ultimately, coma and cardiorespiratory failure develop, which can lead to patient death within 2-18 hours. Monitoring of cardiovascular and respiratory parameters, as well as symptomatic therapy, is recommended. A specific antidote is not known. Drug interactions MAO inhibitors enhance and prolong the anticholinergic effects of Suprastin. Particular caution should be exercised when Suprastin is taken concurrently with other sedatives, tranquilizers, sedative analgesics, tricyclic antidepressants, atropine, and muscarinic parasympatholytics. Suprastin and any of these preparations can enhance each other's effects. Alcohol enhances the depressant effect of Suprastin on the central nervous system, therefore, alcohol consumption should be avoided when taking this preparation. Storage conditions and expiry dates Store at room temperature 15°-25°C, out of reach of children! Expiry date 5 years; expiry date is indicated on the packaging. The preparation should not be used after the expiry date. Dispensing from pharmacy Pharmaceutical product Group II (by prescription)
