Properties
What is it?
LAXIX Composition and Dosage Forms: Tablets: 50 pcs. per pack. 1 tab. Furosemide...........................................................................40 mg Solution for injection: 2 ml ampoule, 10 and 50 pcs. per pack. 1 ml 1 amp. Furosemide.......................................................10 mg 20 mg Clinical-Pharmacological Group: Diuretic Pharmacological Properties: LAXIX is a rapidly acting diuretic. Its mechanism of action is related to the reduction of sodium and chloride ion reabsorption. The effect begins 1 hour after administration and lasts for 6 hours; when administered intravenously, the effect appears after 30 minutes. Pharmacokinetics: When taken orally, the drug is rapidly absorbed from the gastrointestinal tract. Maximum plasma concentration increases with increasing dose. It is 90% bound to plasma proteins. The half-life is 2 hours. Indications: Arterial hypertension, edema, pulmonary edema, ascites, for forced diuresis. Dosage Regimen: The drug dosage is selected individually. In adults, the initial dose is 20-80 mg. If necessary, the dose can be increased by 20-40 mg after 6-8 hours. This dosage is used 1-2 times a day. In children, the initial dose is 2 mg/kg body weight. In case of ineffectiveness, the dose is increased by 1-2 mg/kg after 6-8 hours from the first administration. For arterial hypertension, the initial dose in adults is 80 mg per day. For pulmonary edema, 40 mg is administered intravenously. Side Effects: Drowsiness, dizziness, headache, depression, tremor, decreased memory and impaired coordination, vomiting, nausea, pancreatitis, impotence, hypercholesterolemia, ventricular arrhythmia. Contraindications: - Acute glomerulonephritis; - End-stage renal failure; - Hepatic coma; - Hypokalemia, hyponatremia, alkalosis; - Hypersensitivity to the drug. During pregnancy, LAXIX administration is recommended only for specific indications and for a short period. Since it is excreted in breast milk and also suppresses lactation, breastfeeding should be discontinued when using the drug in this case. Storage Conditions and Expiration Date: The drug should be stored at a temperature not exceeding 25°C. Shelf life - 3 years
